Oral cancer has been rising in alarming numbers in the world which is anticipated to escalate at 70% by 2030.Although a lot of factors are responsible for the disease, genetics, and gene mutations play a major role in uncontrolled proliferation.Another major factor is apoptosis which is programmed cell death.Apoptosis generally happens in two pathways Extrinsic Spindle Drink Mixers pathway which involves trans-membrane receptor-mediated interaction and by Intrinsic pathway which is a mitochondrial-initiated event.
There are Pro-apoptotic genes that support apoptosis like Caspases, TNF, and P53 families, and Anti-apoptotic genes like BCL-2 which stop the programmed cell death leading to cellular proliferation and tumor progression.This study was done to find the role of the anti-apoptotic protein Lecithin BCL2 in varying histological grades of oral squamous cell carcinoma by immunohistochemistry.